Last update
4/5/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
USERS' SCORE
Good
Based on 11 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9.5
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
Read More
9
Eicosapentaenoic acid shows promise
We examined the link between chronic fatigue syndrome (CFS) and essential fatty acids, focusing specifically on eicosapentaenoic acid (EPA). This investigation arose from various studies highlighting the potential role essential fatty acids play in alleviating symptoms associated with CFS.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Read More
8
Eicosapentaenoic acid's potential in CFS
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Read More
Most Useful Reviews
9
Fatigue decreased
8 people found this helpful
Fatigue has diminished significantly! Just a month ago, I felt completely worn out after 20 hours, but now I hardly notice it. I highly recommend this, especially for mothers of multiple children. It truly helps in combating chronic fatigue syndrome!
Read More
9
No fatigue trace
4 people found this helpful
I've been taking DHA-500 omega for three months, and there's no sign of fatigue. My hands, which were usually dry in winter, are now smooth. This omega-3 greatly aids in alleviating chronic fatigue syndrome!
Read More
9
Improved concentration
2 people found this helpful
This omega is remarkable, with a double dose at a great price. After three months, my husband and I feel much better, our fatigue has vanished, and my memory has improved. It remarkably alleviates chronic fatigue syndrome symptoms!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.5
- All Researches
9.5
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
Read More
9
Essential fatty acids aid fatigue syndrome
We conducted a study to evaluate the effectiveness of essential fatty acids, particularly docosahexaenoic acid (DHA), in treating postviral fatigue syndrome, which affects many individuals after a viral infection.
In a double-blind, placebo-controlled setup involving 63 adults, we administered a mixture of essential fatty acids to half of the participants while the other half received a placebo. Each person received eight capsules daily for three months, and we checked their overall condition, fatigue, and other symptoms at various points throughout the study.
Excitingly, we observed significant improvements among those taking the active treatment. After just one month, 74% of participants in the DHA group felt better compared to only 23% in the placebo group. That number rose to 85% at the three-month mark, indicating that while the placebo group reverted to their initial state, those receiving essential fatty acids continued to improve.
Additionally, we saw that the fatty acid levels in patients’ blood cells normalized with treatment, and there were no adverse effects reported. Overall, our findings suggest that DHA, as part of a broader essential fatty acid approach, is a safe and beneficial option for those suffering from postviral fatigue syndrome.
In a double-blind, placebo-controlled setup involving 63 adults, we administered a mixture of essential fatty acids to half of the participants while the other half received a placebo. Each person received eight capsules daily for three months, and we checked their overall condition, fatigue, and other symptoms at various points throughout the study.
Excitingly, we observed significant improvements among those taking the active treatment. After just one month, 74% of participants in the DHA group felt better compared to only 23% in the placebo group. That number rose to 85% at the three-month mark, indicating that while the placebo group reverted to their initial state, those receiving essential fatty acids continued to improve.
Additionally, we saw that the fatty acid levels in patients’ blood cells normalized with treatment, and there were no adverse effects reported. Overall, our findings suggest that DHA, as part of a broader essential fatty acid approach, is a safe and beneficial option for those suffering from postviral fatigue syndrome.
Read More
9
Eicosapentaenoic acid shows promise
We examined the link between chronic fatigue syndrome (CFS) and essential fatty acids, focusing specifically on eicosapentaenoic acid (EPA). This investigation arose from various studies highlighting the potential role essential fatty acids play in alleviating symptoms associated with CFS.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Read More
8
Eicosapentaenoic acid's potential in CFS
We explored the connection between eicosapentaenoic acid (EPA) and chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. The research indicates that individuals suffering from CFS may experience complications linked to persistent viral infections, which could hinder their body's ability to produce necessary fatty acids.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Specifically, the issue revolves around the enzyme delta-6 desaturase, which plays a critical role in the conversion of essential fatty acids like alpha-linolenic acid and linoleic acid into longer chain polyunsaturated fatty acids. These fatty acids are vital for maintaining healthy cell membranes and proper cell signaling. If their production is inhibited, it could explain many symptoms associated with CFS.
One intriguing aspect we observed is the potential therapeutic role that EPA could play. By providing EPA directly, we may bypass some of the metabolic restrictions caused by viral infections. This not only aids in generating essential fatty acids needed for bodily functions but also shows promise as a treatment option that could alleviate certain symptoms of CFS.
While the exact impact of EPA treatment on CFS warrants further investigation, the findings suggest that it might offer some benefits worth considering for those affected by this challenging condition.
Read More
7
We explored the connection between omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), and chronic fatigue syndrome (CFS). In this study, researchers compared serum PUFA levels in 22 patients with CFS to 12 healthy controls.
Their findings revealed that CFS patients had higher levels of omega-6 fatty acids and lower omega-3 levels compared to those without the condition. Specifically, the ratio of omega-3 to omega-6 was significantly lower in CFS patients. This imbalance was correlated with more severe symptoms, such as fatigue and memory problems. The research also suggested that lower zinc levels might be linked to this imbalance and indicate problems with T cell activation, which plays an essential role in immune function.
While the study provides insights into the relationship between omega-3 fatty acids and CFS, it focuses on omega-3s in general and does not isolate the effects of DHA alone. However, it hints that increasing omega-3 PUFA intake, including DHA, could potentially help manage symptoms of CFS, even though further research is needed to confirm this finding.
Their findings revealed that CFS patients had higher levels of omega-6 fatty acids and lower omega-3 levels compared to those without the condition. Specifically, the ratio of omega-3 to omega-6 was significantly lower in CFS patients. This imbalance was correlated with more severe symptoms, such as fatigue and memory problems. The research also suggested that lower zinc levels might be linked to this imbalance and indicate problems with T cell activation, which plays an essential role in immune function.
While the study provides insights into the relationship between omega-3 fatty acids and CFS, it focuses on omega-3s in general and does not isolate the effects of DHA alone. However, it hints that increasing omega-3 PUFA intake, including DHA, could potentially help manage symptoms of CFS, even though further research is needed to confirm this finding.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Fatigue decreased
8 people found this helpful
Fatigue has diminished significantly! Just a month ago, I felt completely worn out after 20 hours, but now I hardly notice it. I highly recommend this, especially for mothers of multiple children. It truly helps in combating chronic fatigue syndrome!
Read More
9
No fatigue trace
4 people found this helpful
I've been taking DHA-500 omega for three months, and there's no sign of fatigue. My hands, which were usually dry in winter, are now smooth. This omega-3 greatly aids in alleviating chronic fatigue syndrome!
Read More
9
Improved concentration
2 people found this helpful
This omega is remarkable, with a double dose at a great price. After three months, my husband and I feel much better, our fatigue has vanished, and my memory has improved. It remarkably alleviates chronic fatigue syndrome symptoms!
Read More
9
Brain energy boost
2 people found this helpful
This omega formula is fantastic! After taking two capsules a day, I've experienced no fishy aftertaste or fatigue. It's economical, aiding significantly in combating chronic fatigue syndrome.
Read More
9
Increased concentration
1 people found this helpful
When taking this DHA supplement, I feel a noticeable boost in brain energy and concentration. It helps combat fatigue and brain fog, significantly aiding my chronic fatigue syndrome. A very good product!
Read More
Frequently Asked Questions
9
Fatigue decreased
8 people found this helpful
Fatigue has diminished significantly! Just a month ago, I felt completely worn out after 20 hours, but now I hardly notice it. I highly recommend this, especially for mothers of multiple children. It truly helps in combating chronic fatigue syndrome!
9
Improved concentration
2 people found this helpful
This omega is remarkable, with a double dose at a great price. After three months, my husband and I feel much better, our fatigue has vanished, and my memory has improved. It remarkably alleviates chronic fatigue syndrome symptoms!
7.5
Body improvement
4 people found this helpful
I order this for my family regularly and take it with vitamin D3. It significantly improves our overall wellbeing, especially in Moscow, where chronic fatigue syndrome is prevalent. This omega nourishes well and makes winter more bearable.
9
Increased concentration
1 people found this helpful
When taking this DHA supplement, I feel a noticeable boost in brain energy and concentration. It helps combat fatigue and brain fog, significantly aiding my chronic fatigue syndrome. A very good product!
9
Brain energy boost
2 people found this helpful
This omega formula is fantastic! After taking two capsules a day, I've experienced no fishy aftertaste or fatigue. It's economical, aiding significantly in combating chronic fatigue syndrome.
7
We explored the connection between omega-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), and chronic fatigue syndrome (CFS). In this study, researchers compared serum PUFA levels in 22 patients with CFS to 12 healthy controls.
Their findings revealed that CFS patients had higher levels of omega-6 fatty acids and lower omega-3 levels compared to those without the condition. Specifically, the ratio of omega-3 to omega-6 was significantly lower in CFS patients. This imbalance was correlated with more severe symptoms, such as fatigue and memory problems. The research also suggested that lower zinc levels might be linked to this imbalance and indicate problems with T cell activation, which plays an essential role in immune function.
While the study provides insights into the relationship between omega-3 fatty acids and CFS, it focuses on omega-3s in general and does not isolate the effects of DHA alone. However, it hints that increasing omega-3 PUFA intake, including DHA, could potentially help manage symptoms of CFS, even though further research is needed to confirm this finding.
Their findings revealed that CFS patients had higher levels of omega-6 fatty acids and lower omega-3 levels compared to those without the condition. Specifically, the ratio of omega-3 to omega-6 was significantly lower in CFS patients. This imbalance was correlated with more severe symptoms, such as fatigue and memory problems. The research also suggested that lower zinc levels might be linked to this imbalance and indicate problems with T cell activation, which plays an essential role in immune function.
While the study provides insights into the relationship between omega-3 fatty acids and CFS, it focuses on omega-3s in general and does not isolate the effects of DHA alone. However, it hints that increasing omega-3 PUFA intake, including DHA, could potentially help manage symptoms of CFS, even though further research is needed to confirm this finding.
9
Eicosapentaenoic acid shows promise
We examined the link between chronic fatigue syndrome (CFS) and essential fatty acids, focusing specifically on eicosapentaenoic acid (EPA). This investigation arose from various studies highlighting the potential role essential fatty acids play in alleviating symptoms associated with CFS.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
Our approach involved administering a high-EPA supplementation to a group of individuals diagnosed with chronic fatigue syndrome. After following these patients for eight to twelve weeks, we observed that all participants experienced notable improvements in their symptoms.
These positive changes align with recent findings that discuss both cerebral and clinical benefits tied to increased EPA intake. Given these encouraging results, eicosapentaenoic acid may ultimately provide hope for many suffering from chronic fatigue syndrome.
9.5
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.
This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
References
- Maes M, Mihaylova I, Leunis JC. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett. 2005;26:745. PubMed
- Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990;82:209. PubMed
- Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol. 2007;60:122. PubMed
- Puri BK, Holmes J, Hamilton G. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004;58:297. PubMed
- Puri BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prostaglandins Leukot Essent Fatty Acids. 2004;70:399. PubMed
Data last updated:
